ASA 2011

Evan D. Kharasch, MD PhD is the Vice Chancellor for Research at Washington University in St. Louis. He is also the Russell D. and Mary B. Shelden Professor of Anesthesiology, and Director of the Division of Clinical and Translational Research in the Department of Anesthesiology, and Professor of Biochemistry and Molecular Biophysics.

Professor Kharasch is a practicing anesthesiologist, with interests ranging from outpatient to high-risk anesthesia. His research interests include clinical pharmacology of anesthetic and analgesic drugs. The overall goal of his research program is to understand the role of hepatic and extra-hepatic drug metabolism and drug transport in the pharmacokinetics, pharmacodynamics, pharmacogenetics, toxicity, and variability in patient response. These are directed towards optimizing drug disposition, drug safety, clinical effectiveness, and patient satisfaction. Major project areas include mechanisms of interindividual variability in opioid disposition and clinical response, role of transporters in drug response, influence of HIV/AIDS drug interactions on drug metabolism and transport, and the development of novel noninvasive methods for assessing hepatic and intestinal cytochrome P450 activity in humans.